Wow, like that it sounds like you're gonna have to keep the male quite far away to prevent the hormones from reaching him. It's a bit impossible cos the hormones can travel very far in the air via their pee. I watched it on tv. The show didn't say how far away, just that if a female dog in a neighbourhood is in heat, most of the dogs in the same neighbourhood know. Doesn't matter if you keep her locked up. Unless you keep her in an airtight container or something (just kidding).

I dunno how to treat stress due to hormones, but I know that they are selling stress-relieving, all-natural, aromatherapy plus chemical type vials in pet shops now. All the ingredients in the bottle are natural and there are different types of "treatment". Some to "calm", some to induce sleep, some to "relieve stress". You feed it to the dog, not let it smell. One brand is Richard's Organics. There are other brands. I dunno if this will help, but you can consider it.